This is a notebook within a series on Greider's diagrams and request forms for Oligomers. The notebook begins with a discussion on the alignment of E. crassus, a ciliate, and the tetrahymena telomerase RNA (note abundance of Uracil) It accompanies a diagram of RNA telomerase with the discussed alignment.Note how the Uracil nucleotide is interestingly linked to Adenine in a 3 prime 5 prime structure and how the Z-fold 159 RNA nucleotides of the diagram are the telomerase RNA component. Telomerase RNA’s differ greatly in sequence between vertebrates, ciliates, like Tetrahymena and yeast, but they share a 5 prime pseudo knot structure close to the template sequence. She outilined three important aspects of the telomerase RNA component diagrams. The first is the 3 prime oligo series with nucleotide numbers in the sequence. The second are the secondary structures of 159 RNA telomerase. Finally, the thirs is 5 prime to 3 prime structure and the second document has RNA sequences and with complementary region of length. In this section she also sketched the 159 RNA Telomerase in a Z-fold. Greider detailed the complementary region of length, the closed bifurcation between two regions, and its interior loops. The notebook ends with a series of request forms.
Scope and Contents
This is a notebook within a series on Greider's diagrams and request forms for Oligomers. The notebook begins with a discussion on the alignment of E. crassus, a ciliate, and the tetrahymena telomerase RNA (note abundance of Uracil) It accompanies a diagram of RNA telomerase with the discussed alignment.Note how the Uracil nucleotide is interestingly linked to Adenine in a 3 prime 5 prime structure and how the Z-fold 159 RNA nucleotides of the diagram are the telomerase RNA component. Telomerase RNA’s differ greatly in sequence between vertebrates, ciliates, like Tetrahymena and yeast, but they share a 5 prime pseudo knot structure close to the template sequence. She outilined three important aspects of the telomerase RNA component diagrams. The first is the 3 prime oligo series with nucleotide numbers in the sequence. The second are the secondary structures of 159 RNA telomerase. Finally, the thirs is 5 prime to 3 prime structure and the second document has RNA sequences and with complementary region of length. In this section she also sketched the 159 RNA Telomerase in a Z-fold. Greider detailed the complementary region of length, the closed bifurcation between two regions, and its interior loops. The notebook ends with a series of request forms.
Preferred Citation
RNA Folding, 1987. Carol Greider Collection, Cold Spring Harbor Laboratory Archives Digital Repository. 88-1525512. Update 2025-03-18.
Credit Line
Courtesy of Cold Spring Harbor Laboratory Archives.
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